98. Hormonal influences in hereditary breast cancer

Hereditary Breast-Ovarian Cancer

Gene assembling: a new approach in molecular diagnosis of hereditary breast cancer

 Abstract Background: Many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. Scanning each exon individually represents a tedious task which can be time consuming and expensive. There has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. Gene Assembling i...

Prophylaxis of hereditary breast cancer

Hereditary breast and ovarian cancer

Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. The first documentation of familial clustering of breast cancer in modern times was published by Broca, who reported 10 cases of breast cancer in 4 generations of his wife’s family [2]. In the middle of the nineteen nineties it was proven at the molecular level that a substantial number of breast and ovar...

Hormonal resistance in breast- and prostate cancer

Breast and prostate cancers are the most common malignant disease in female and male world population, respectively. Both of these tumors are predominantly hormonal-dependent, what is rationale for the widely used endocrine treatment, with specific approach in each of them. Although endocrine treatment is obviously effective and responsible for prolonged progression-free survival and even survi...